ELEVATED INFLAMMATORY RESPONSES AND TARGETED THERAPEUTIC INTERVENTION IN A PRECLINICAL MOUSE MODEL OF ATAXIA-TELANGIECTASIA LUNG DISEASE

Elevated inflammatory responses and targeted therapeutic intervention in a preclinical mouse model of ataxia-telangiectasia lung disease

Abstract Ataxia-telangiectasia (A-T) is an autosomal recessive, multisystem disorder characterized by cerebellar degeneration, cancer predisposition, and immune system defects.A major cause of mortality in A-T patients is severe pulmonary disease; however, the underlying causes of the lung complications are poorly understood, and there are currentl

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On the arclength of trigonometric interpolants

As pointed out recently by Strichartz [5], the arclength of the graph (Gamma(S_N(f))) of the partial sums (S_N(f)) of the Fourier series BMX Chain Spares of a jump function (f) grows with the order of (log N).In this paper we discuss the behaviour of the arclengths of the graphs of trigonometric interpolants to a jump function.Here the boundedness

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TRPS1 modulates chromatin accessibility to regulate estrogen receptor alpha (ER) binding and ER target gene expression in luminal breast cancer cells.

Common genetic variants in the repressive GATA-family transcription factor (TF) TRPS1 locus are associated with breast cancer risk, and luminal breast cancer cell lines are particularly sensitive to TRPS1 knockout.We introduced an inducible degron tag into the native TRPS1 locus within a luminal breast cancer cell line to identify the direct target

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